BioMaths Colloquium Series – 2022/23
1 March 2023 15 March 2023 – 3pm
CANCELLED DUE TO STRIKE ACTION
Bay Campus – Computational Foundry
Join us in room 209 at 2:45 for coffee tea and biscuits
or on Zoom (register here)
Modelling Microtube Driven Invasion of Glioma
Our BioMaths Colloquium Series continues with a seminar by Professor Thomas Hillen from the University of Alberta. Thomas Hillen obtained his PhD from the University of Tuebingen, Germany, under supervision of Prof. K.P. Hadeler. After postdocs in Tuebingen and Salt Lake City, he became professor at the Department of Mathematical and Statistical Sciences at the University of Alberta. His main research interests include the mathematical modeling of cancer, cancer growth, diagnosis, and treatment with an emphasis on cell movement behavior. Dr. Hillen has been President of the Canadian. Applied and Industrial Mathematical Society (CAIMS) and currently serves as PIMS Site Director at the University of Alberta. Since January 2022 he is Editor in Chief of the Journal of Mathematical Biology.
Malignant gliomas are highly invasive brain tumors. Recent attention has focused on their capacity for network-driven invasion, whereby mitotic events can be followed by the migration of nuclei along long thin cellular protrusions, termed tumour microtubes (TM). Here I develop a mathematical model that describes this microtube-driven invasion of gliomas. I show that scaling limits lead to well known glioma models as special cases such as go-or-grow models, the PI model of Swanson, and the anisotropic model of Swan.
Numerical simulations are used to compare between the models. (Joint work with N. Loy, K.J. Painter, R. Thiessen).