The only constant is change…in the tumor microenvironment

BioMaths Colloquium Series – 2025/26
13 November 2025 – 3pm Wallace Zoology Museum (Singleton Campus)
Register here to attend the colloquium on Zoom

Professor David Basanta

(Moffitt Cancer Center, Tampa, USA)

Our BioMaths Colloquium Series continues with a seminar by David Basanta from the Integrated Mathematical Oncology ar the H. Lee Moffitt Cancer Center in Florida, USA. David leads the CancerEvo lab, a group of mathematical modellers, working with biologists and clinicians, to understand the ecology of tumors and the evolutionary dynamics of cancer progression and resistance to treatment.

Abstract

The tumor microenvironment (TME) is a critical factor in cancer initiation, progression, and treatment resistance. However, a lack of tools to study its dynamic nature has hindered our understanding of these key interactions, which likely explains important aspects of cancer progression and provides potential therapeutic targets. Our work introduces an integrated approach combining preclinical data, spatial statistics, mathematical modeling, and evolutionary learning to study TME dynamics. Our goal is to fill these knowledge gaps and design new treatment schedules that can prevent or delay the emergence of treatment resistance in cancer.